Neonatal sepsis and other neonatal infections

Disease Description

Case definition in GBD 2017

Neonatal sepsis and other neonatal infections are infections during the neonatal period that advance to a systemic bloodstream infection, the underlying cause of which can be meningitis, gastroenteritis, or other aetiologies. Neonatal pneumonia, however, is not included – it is captured in the modelling of pneumonia as a separate entity.

Todo

Add more information and references. In particular, find data about differences in global and gbd definitions, global prevalence and relation to folic acid during pregnancy.

Modeling Neonatal sepsis and other infections in GBD 2017

It is worth noting that the ICD 10 and ICD 9 codes used in non-fatal and fatal GBD models are different [GBD-2017-YLD-Capstone-Appendix-1-Neonatal-sepsis-and-other-infections], [GBD-2017-CoD-Appendix-1-Neonatal-sepsis-and-other-infections].

The codes used in both models can be found in the table below:

Neonatal sepsis and other neonatal infections - ICD codes

Model Type

Non-fatal model

Fatal model

ICD 10

P36-P36.9, P38-P39.9

P36-P36.9, P38-P39.9

ICD 10 used in Hospital/Claims Analyses

K29.0-K29.00, K29.1-K29.20, P36-P36.9, P38-P39.9, P77-P78.1

ICD 9

771, 771.4-771.89

771.4-771.9

ICD 9 used in Hospital/Claims Analyses

535.0-535.00, 535.3-535.30, 771, 771.4-771.89, 777.5-777.7

Todo

Add relevant details about neonatal sepsis and other infections modeling process from [GBD-2017-YLD-Capstone-Appendix-1-Neonatal-sepsis-and-other-infections] and from the [GBD-2017-CoD-Appendix-1-Neonatal-sepsis-and-other-infections] Appendix.

Cause Hierarchy

Neonatal sepsis GBD hierarchy diagram

Cause Model Diagram

SI cause model diagram for neonatal sepsis and other infections

Data Description

Definitions

State

State Name

Definition

S

Susceptible

Susceptible to neonatal sepsis and other infections

I

Infected

Infected with neonatal sepsis and other infections
States Data

State

Measure

Value

Notes

S

prevalence

1-prevalence_c383

S

birth prevalence

1-birth_prevalence_c383

S

excess mortality rate

0

S

disabilty weights

0

I

prevalence

prevalence_c383

I

birth prevalence

birth_prevalence_c383

I

excess mortality rate

\(\frac{\text{deaths\_c383}}{\text{population} \times \text{prevalence\_c383}}\)

= (cause-specific mortality rate) / prevalence

I

disability weights

\(\displaystyle{\sum_{s\in \text{sequelae\_c383}}} \scriptstyle{\text{disability\_weight}_s \,\times\, \text{prevalence}_s}\)

= average disability weight over all sequelae

ALL

cause specific mortality rate

\(\frac{\text{deaths\_c383}}{\text{population}}\)
Transition Data

Transition

Source

Sink

Value

Notes

i

S

I

incidence_rate_m1594

Incidence rate is estimated in dismod but does not exists in como. It is set to 0 after 27 days as by definition neonatal sepsis must occur within neonatal period (0-27 days) [GBD-2017-YLD-Capstone-Appendix-1-Neonatal-sepsis-and-other-infections].

r

I

R

remission_rate_m1594

Remission rate is estimated in dismod based on the average case duration assumption of two weeks [GBD-2017-YLD-Capstone-Appendix-1-Neonatal-sepsis-and-other-infections].
Data Sources

Measure

Sources

Description

Notes

prevalence_c383

como

Prevalence of cause neonatal sepsis and other infections

birth_prevalence_c383

como

Birth prevalence of cause neonatal sepsis and other infections

deaths_c383

codcorrect

Deaths from cause neonatal sepsis and other infections

population

demography

Mid-year population for given age/sex/year/location

sequelae_c383

gbd_mapping

List of 17 sequelae for neonatal sepsis and other infections.

The sequela ids are in sequence from 1250 to 1266

incidence_rate_m1594

dismod

Incidence rate for modelable entity, neonatal sepsis and other infections

remission_rate_m1594

dismod

Remission rate for modelable entity, neonatal sepsis and other infections

disability_weight_s{sid}

YLD appendix

Disability weight of sequela with id sid

prevalence_s{sid}

como

Prevalence of sequela with id sid

Model Assumptions and Limitations

Restrictions

The following table describes any restrictions on the effects of this cause (such as being only fatal or only nonfatal), as well as restrictions on the age and sex of simulants to which different aspects of the cause model apply.

Restrictions

Restriction Type

Value

Notes

Male only

False

Female only

False

YLL only

False

YLD only

False

YLL age group start

Early neonatal

GBD age group id 2

YLL age group end

Post neonatal

GBD age group id 4

YLD age group start

Early neonatal

GBD age group id 2

YLD age group end

95 plus

GBD age group id 235

Todo

Add assumptions and limitations.

Validation Criteria

Todo

Describe tests for model validation.

References